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GACT09
Genetic Architecture of Complex TraitsCourse Timetable (provisional, last revised Dec 7th) |
| GACT09 | Genetic Architecture of Complex Traits |
| Wed, Dec 9th |
Day #1
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| 09:30 - 11:00 | Introduction. Forms of Genomic Variation. Linking Genotypes and Phenotypes. diseases as a phenotype. Disease types: the Mendelian to complex spectrum. How do we know that a disease has a genetic component? Heritability. |
| 11:00 - 11:30 | Coffee Break |
| 11:30 - 12:30 | Quantifying heritability: family studies, adoption studies, twins. A quick overview of classical QTL analysis. |
| 12:30 - 14:00 | Lunch Break |
| 14:00 - 16:00 | Association studies and their Whole Genome Extensions. Design and Analysis of Association studies and Genome-Wide Association Studies (GWAS). Candidate-Gene vs. Genome-wide approaches. |
| 16:00 - 16:30 | Tea Break |
| 16:30 - 18:00 | Challenges of WGASs (I). Adding biology into the analysis. Testing for interactions. High order analysis. Haplotype analysis and simultaneous analysis of all SNPs. |
| Thu, Dec 10th |
Day #2
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| 09:30 - 11:00 | Challenges of GWASs (I). The multiple testing problem and correction procedures. The problem of lack of replicability. Publication biases. The mystery of the missing heritability. Adding biology into the analysis. Haplotype analysis and simultaneous analysis of all SNPs. Testing for interactions. High order analysis. |
| 11:00 - 11:30 | Coffee Break |
| 11:30 - 12:30 | Challenges of WGASs (III). Structural Variation in the Genome. Copy Number Variants and WGAS |
| 12:30 - 14:00 | Lunch Break |
| 14:00 - 16:00 | Practical Session II. More on SNPator. Performing an association study I. |
| 16:00 - 16:30 | Tea Break |
| 16:30 - 18:00 | Practical Session III. More on SNPator. Performing an association study II. Introduction to Plink. |
| Fri, Dec 11th |
Day #3
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| 09:30 - 11:00 | Overview of recent GWASs and Metaanalysis. Some lessons we learned from them. |
| 11:00 - 11:30 | Coffee Break |
| 11:30 - 12:30 | Next Generation Sequencing and deep-sequencing. The 1000 genomes and Public Projects in Population Genomics (P3G). What else can we expect? Unknown unknowns in the genome. |
| 12:30 - 14:00 | Lunch Break |
| 14:00 - 16:00 | Practical Session IV. More on SNPator. Haplotype estimation. PHASE and FastPHASE, Haploview and other packages. |
| 16:00 - 16:30 | Tea Break |
| 16:30 - 18:00 | Practical Session V. Copy Number Variants, a practical approach. Birdsuite and other packages. |
| GACT09 Homepage |
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Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal Last updated: December 7th 2009 |