Structural Genomics

   Deadline for applications: July 20th 2009
   Notification of acceptance date: July 21st 2009
   Course date: July 27th - July 31st 2009


Marc A. Marti-Renom has 14 years of experience in international academic institutions. Since July 2006 Head of the Structural Genomics Unit at the CIPF, Valencia (Spain). He obtained his Ph.D. in January 1999 under the supervision of Profs. Martin Karplus, Francesc X. Aviles, and Baldomero Oliva. He was Postdoctoral Fellow and Research Associate at the Rockefeller University (1999-2003). Assistant Adjunct Professor at the University of California at San Francisco (2003-2006). Key personnel in three funded NIH grants. Member of the Admissions Committee at the School of Pharmacy at UCSF (2003-2006). Up-to-date, his research has resulted in 39 peer-reviewed articles, 2 invited reviews, 9 book chapters and 12 invited presentations in international conferences. He has directed the development of two major software packages (EVA-CM and DBAli) as well as has significantly contributed to the MODBASE, MODPIPE and MODELLER software packages. Detailed information about his research can be found at

Centro de Investigación Príncipe Felipe. Valencia. Spain.

Antonio Pineda-Lucena got his PhD at the Centro de Investigaciones Biologicas (CSIC, Madrid, Spain) in 1995. After that, he moved to the Netherlands (EMBO and Marie Curie fellowships) to work as a postdoctoral researcher with Prof. Dr. Cees Hilbers at the University of Nijmegen. Later on, he got a position as an Associate Scientist at the Ontario Cancer Institute in Toronto (Canada), the canadian reference centre for cancer treatment, where he was working in the structural characterization of oncoproteins and tumor suppressors, as well as in the development of new technologies for structural genomics. Two years later, he accepted a position in one of the biggest pharmaceutical companies, AstraZeneca (Manchester, UK). APL joined the Centro de Investigacion Principe Felipe (CIPF) in February, 2005 to head the Laboratory of Structural Biology and the NMR facility. The group has three other members (a Ramon y Cajal senior researcher, three postdoctoral researchers and a technician), with experience in NMR, organic chemistry, cell biology, microbiology, protein chemistry, computational chemistry, cheminformatics and drug design using fragment-based screening.
Centro de Investigación Príncipe Felipe. Valencia. Spain.

Course description:

Structure determination and prediction (days 1 and 2), human variability and pharmacogenomics (day 3), docking of small molecules from an experimental and computational perspective (day 4) and quantitative structure-activity relationships (day 5).
This course is addressed to students with some knowledge of structural biology as well as computational biology. However, the course aims to introduce the students to the theoretical background as well as some practical applications. Attendees will be trained in the usage of public domain software for:

- Protein structure determination from NMR
- Structure prediction (MODELLER)
- SNP analysis
- Docking of small molecules by (DOCK)
- QSAR analysis and generation of ligand libraries

During the five days of the course, we will teach several topics relevant to other areas such as structure-based drug discovery.

Course Pre-requisites:

Basic Molecular Biology. Elementary computing skills.

Detailed Program

Instituto Gulbenkian de Ciência,

Apartado 14, 2781-901 Oeiras, Portugal

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Last updated:  June 18th 2009