Structural Genomics and Drug Design

   Deadline for applications: Sept 7th 2010
        EARLY: August 30th 2010
        NORMAL: September 10th 2010
   Course date: September 20th - September 24th 2010


Marc A. Marti-Renom After obtaining his PhD at the Universitat Autónoma de Barcelona in January 1999, under the supervision of Profs. Martin Karplus, Francesc X. Avilés, and Baldomero Oliva, he moved to the Rockefeller University (New York, USA) were he was the recipient of the Burroughs Wellcome Fund fellowship for interdisciplinary research in physics, chemistry, and computation. Between 2002 and 2003 he was promoted to Research Associate at the Rockefeller University and then, in February 2003, appointed as Assistant Adjunct Professor by the University of California at San Francisco. During his time at the UCSF he was key personnel in three funded NIH grants. Between 2003 and 2007, he has also served as member of the Admissions Committee at the School of Pharmacy (UCSF). Since 2002 he has given invited presentations in more than 30 international conferences, and regularly taught comparative modeling. Up to now, his research has resulted in 50 peer-reviewed articles, and 10 book chapters or invited reviews. He has also played a leader role for a large number of projects, which included the design and development of two major software packages (EVA-CM and DBAli) as well as has significantly contributed to the MODBASE, MODPIPE, MODELLER and IMP packages. He has taught Structural Genomics in GTPB twice before.

Centro de Investigación Príncipe Felipe. Valencia. Spain.

Antonio Pineda-Lucena got his PhD at the Centro de Investigaciones Biologicas (CSIC, Madrid, Spain) in 1995. After that, he moved to the Netherlands (EMBO and Marie Curie fellowships) to work as a postdoctoral researcher with Prof. Dr. Cees Hilbers at the University of Nijmegen. Later on, he got a position as an Associate Scientist at the Ontario Cancer Institute in Toronto (Canada), the canadian reference centre for cancer treatment, where he was working in the structural characterization of oncoproteins and tumor suppressors, as well as in the development of new technologies for structural genomics. Two years later, he accepted a position in one of the biggest pharmaceutical companies, AstraZeneca (Manchester, UK). APL joined the Centro de Investigacion Principe Felipe (CIPF) in February, 2005 to head the Laboratory of Structural Biology and the NMR facility. The group has three other members (a Ramon y Cajal senior researcher, three postdoctoral researchers and a technician), with experience in NMR, organic chemistry, cell biology, microbiology, protein chemistry, computational chemistry, chemical compound analysis and drug design using fragment-based screening. He has taught Structural Genomics in GTPB twice before.
Centro de Investigación Príncipe Felipe. Valencia. Spain.

Course description:

Structure determination and prediction (days 1 and 2), human variability and pharmacogenomics, docking of small molecules from an experimental and computational perspective (day 3), quantitative structure-activity relationships (day 4), and practical example (day 5). The course is addressed to students with some knowledge of structural biology as well as computational biology. However, the course aims to introduce the students to the theoretical background as well as some practical applications. Attendees will be trained in the usage of public domain software for:
- Protein structure determination from NMR
- Structure prediction with MODELLER
- SNP analysis
- Docking of small molecules with AutoDock Vina
- Cheminformatics and generation of ligand libraries
During the five days of the course, we will teach several topics relevant to other areas such as structure-based drug discovery.

Course Pre-requisites:

Basic Molecular Biology. Elementary computing skills.

Detailed Program

Instituto Gulbenkian de Ciência,

Apartado 14, 2781-901 Oeiras, Portugal

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Last updated:  August 1st 2010