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GACT11
Genetic Architecture of Complex TraitsCourse Timetable |
| GACT11 | Genetic Architecture of Complex Traits |
| Wed, Jan 19th |
Day #1
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| 09:30 - 11:00 | Introduction. Forms of Genomic Variation. Linking Genotypes and Phenotypes. Diseases as a phenotype. Disease types: the Mendelian to complex spectrum. How do we know that a disease has a genetic component? Heritability. |
| 11:00 - 11:30 | Coffee Break |
| 11:30 - 12:30 | Association studies and their Whole Genome Extensions. Design and Analysis of Association studies and Genome-Wide Association Studies (GWAS). Candidate-Gene vs. Genome-wide approaches. |
| 12:30 - 14:00 | Lunch Break |
| 14:00 - 16:00 | Practical Session I. SNP selection for candidate Gene approaches and Association Analysis I (SYSNPs). Introduction to SNPator, GWASpi and PLINK. |
| 16:00 - 16:30 | Tea Break |
| 16:30 - 18:00 | Challenges of GWASs (I). The multiple testing problem and correction procedures. |
| Thu, Jan 20th |
Day #2
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| 09:30 - 11:00 | Challenges of GWASs (II). The problem of lack of replicability. Publication biases. The mystery of the missing heritability. Adding biology into the analysis. Haplotype analysis and simultaneous analysis of all SNPs. Testing for interactions. High order analysis. |
| 11:00 - 11:30 | Coffee Break |
| 11:30 - 12:30 | Challenges of GWASs (II). Structural Variation in the Genome. Copy Number Variants and GWAS. |
| 12:30 - 14:00 | Lunch Break |
| 14:00 - 16:00 | Practical Session II. More on SNPator, GWASpi and PLINK. Performing an association study I. |
| 16:00 - 16:30 | Tea Break |
| 16:30 - 18:00 | Practical Session III. More on SNPator. Performing an association study II. |
| Fri, Jan 21st |
Day #3
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| 09:30 - 11:00 | Overview of recent GWASs and Metaanalysis. Some lessons we learned from them. |
| 11:00 - 11:30 | Coffee Break |
| 11:30 - 12:30 | Next Generation Sequencing and deep-sequencing. The 1000 genomes and Public Projects in Population Genomics (P3G). What else can we expect? Unknown unknowns in the genome. |
| 12:30 - 14:00 | Lunch Break |
| 14:00 - 16:00 | Practical Session IV. Performing an association study III. Annotating the results. Databases. Haploview and other packages. |
| 16:00 - 16:30 | Tea Break |
| 16:30 - 18:00 | Practical Session V. Copy Number Variants, a practical approach. Birdsuite and other packages. |
| Course Homepage |
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Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal Last updated: December 15th 2010 |