BIG12

Bioinformatics for Integrative Genomics

Exploring and making sense of multidimensional data sets that result from merging heterogeneous genomic data resources

   IMPORTANT DATES for BIG12
   Deadline for applications: April 15th 2012
   Notification of acceptance dates:
        EARLY: April 10th 2012
        NORMAL: April 17th 2012
   Course date: May 7th, 8th and 9th 2012

Instructors:

Abel Gonzalez-Perez obtained his PhD in Bioinformatics from the University of Havana, Cuba in 2006. He worked as a postdoctoral researcher at the Cuban National Bioinformatics Institute between 2006 and 2008. He has done comparative studies of the transcriptional regulatory networks of bacteria, and signaling pathways in eukaryotes. Since August 2010 he is a postdoctoral researcher at the Biomedical Genomics Group of the Universitat Pompeu Fabra. Currently, he works in the assessment of the functional impact of genomic variants, the identification of cancer driver genes and pathways and in the integration and analysis of various cancer genomics data.

Michael P. Schroeder is a Biologist from the Universitat Pompeu Fabra. He has a Master in Bioinformatics from the Universitat Pompeu Fabra he is currently pursuing a PhD at the Biomedical Genomics Group of the same University. His main interests are the study of the effect of genomic alterations in cancer and the identification of functional relationships between cancer alterations.

Affiliation:

Universitat Pompeu Fabra (UPF), Barcelona, ES

Course description:

The application of high-throughput technologies in medical genomics yields complex, multidimensional data sets that describe in detail the myriad changes that occur within individual cells and how these changes differ between patients, cells or conditions. Usually we want to use this data to answer some specific questions. For instance, which of the long list of mutations detected are likely to affect the function of the protein and which are probably neutral? Which of the genes affected by those mutations are already known to be involved in cancer or other diseases? Which pathways or biological processes are affected by the transcriptomic alterations detected in my experiment? Etc.

We need to apply bioinformatic approaches to answer these questions. This course provides theoretical and practical expertise in the field of bioinformatics for integrative genomics. Students are updated on the state of the art in the field and they become capable of handling and analyzing genomics data. Upon completion, the attendees are able to perform integrative analysis and interpret the results, in order to answer specific biological questions.

To achieve these objectives we will extensively use three tools developed in the Biomedical Genomics Group of UPF: IntOGen, Gitools and Condel. You can check the blog of the group to learn more about those tools. We will also explore a large set of web accessible data resources and software.

Target Audience:

The course is directed to researchers in biology and medicine. Background knowledge in bioinformatics is not necessary.

Course Pre-requisites:

Basic Molecular Biology. Elementary computing skills.

Detailed Program

In collaboration with INTERBIO

Sponsorship available for members of the following INTERBIO Nodes:
- Université Paul Sabatier Toulouse - UPS (Midi-Pyrénées - France) (www.ups-tlse.fr)
- Fundación Privada BioRegió de Catalunya - BIOCAT (Catalonia - Spain), (www.biocat.cat)
- Institut Européen de Chimie et Biologie - IECB (Aquitaine - France), (www.iecb.u-bordeaux.fr)
- Fundación de la Comunidad Valenciana para la Innovación Urbana y Economía del Conocimiento - FIVEC (Valencia - Spain), (www.fivec.org).

If you wish to apply as a member of one of these institutions, please contact your local INTERBIO representative.

Instituto Gulbenkian de Ciência,

Apartado 14, 2781-901 Oeiras, Portugal

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Last updated: March 23rd 2012