Metabolic Pathway Analysis

   Deadline for applications: May 11th 2012
   Notification of acceptance dates:
        EARLY: May 4th 2012
        NORMAL: May 12th 2012
   Course date: May 21st - May 23rd 2012


Stefan Schuster studied Biophysics at Humboldt University, Berlin. In 1988 he received his PhD in Theoretical Biophysics. He worked as a Postdoc in Berlin, Bordeaux and Amsterdam. From 1997-2003, he was a group leader at the Max Delbrück Center, Berlin-Buch, still teaching at Humboldt University. Since May 2003, he is the head of the Chair of Bioinformatics at the Faculty of Biology and Pharmacy, Friedrich Schiller University Jena. His main scientific interests are in mathematical modelling of metabolism and cellular signalling and in evolutionary game theory. He is one of the editors of the journal BioSystems.

Friedrich Schiller University, Jena, DE

Christoph Kaleta studied Bioinformatics at the Friedrich Schiller University, Jena. In 2008 he started his PhD in the group of Stefan Schuster, Friedrich Schiller University which he finished in 2010. Since July 2011, he is appointed as Assistant Professor of Theoretical Systems Biology at the Friedrich Schiller University. His main research interests are the analysis of large-scale experimental data sets in the context of metabolic networks and questions relating to the evolutionary adaptation of organisms.

Friedrich Schiller University, Jena, DE

Course description:

Within the growing field of Systems Biology, the mathematical modelling of metabolic networks plays a very important role. This has manifold medical and biotechnological applications, including the analysis and prediction of the effect of enzyme deficiencies, the detection of disease markers, the improvement of biosyntheses and bioproduction processes etc. In this course, we outline the basics and essential tools of Metabolic Pathway Analysis. After a short introduction into enzyme kinetics, we present the concepts of stoichiometry matrix, null-space, elementary modes and conservation relations. Moreover, the basic ideas of Flux Balance Analysis will be explained. In hands-on tutorials, software such as METATOOL, YANASquare, and GEPASI will be used.

Target Audience:
The course is directed to researchers in biology, bioinformatics, biochemistry and medicine. Background knowledge in bioinformatics is not necessary.

Course Pre-requisites:
Basic biochemistry. Elementary computing skills

Detailed Program

In collaboration with INTERBIO

Sponsorship available for members of the following INTERBIO Nodes:
- Université Paul Sabatier Toulouse - UPS (Midi-Pyrénées - France) (
- Fundación Privada BioRegió de Catalunya - BIOCAT (Catalonia - Spain), (
- Institut Européen de Chimie et Biologie - IECB (Aquitaine - France), (
- Fundación de la Comunidad Valenciana para la Innovación Urbana y Economía del Conocimiento - FIVEC (Valencia - Spain), (

If you wish to apply as a member of one of these institutions, please contact your local INTERBIO representative.

Instituto Gulbenkian de Ciência,

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Last updated:  April 10th 2012