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MPA12 Metabolic Pathway Analysis |
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IMPORTANT DATES for MPA12
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Instructors: |
Stefan Schuster studied Biophysics at Humboldt University, Berlin. In
1988 he received his PhD in Theoretical Biophysics. He worked as a
Postdoc in Berlin, Bordeaux and Amsterdam. From 1997-2003, he was a
group leader at the Max Delbrück Center, Berlin-Buch, still teaching
at Humboldt University. Since May 2003, he is the head of the Chair of
Bioinformatics at the Faculty of Biology and Pharmacy, Friedrich
Schiller University Jena. His main scientific interests are in
mathematical modelling of metabolism and cellular signalling and in
evolutionary game theory. He is one of the editors of the journal
BioSystems. |
Christoph Kaleta studied Bioinformatics at the Friedrich Schiller University,
Jena. In 2008 he started his PhD in the group of Stefan Schuster, Friedrich
Schiller University which he finished in 2010. Since July 2011, he is
appointed as Assistant Professor of Theoretical Systems Biology at the
Friedrich Schiller University. His main research interests are the analysis of
large-scale experimental data sets in the context of metabolic networks and
questions relating to the evolutionary adaptation of organisms. |
Course description:Within the growing field of Systems Biology, the mathematical modelling of metabolic networks plays a very important role. This has manifold medical and biotechnological applications, including the analysis and prediction of the effect of enzyme deficiencies, the detection of disease markers, the improvement of biosyntheses and bioproduction processes etc. In this course, we outline the basics and essential tools of Metabolic Pathway Analysis. After a short introduction into enzyme kinetics, we present the concepts of stoichiometry matrix, null-space, elementary modes and conservation relations. Moreover, the basic ideas of Flux Balance Analysis will be explained. In hands-on tutorials, software such as METATOOL, YANASquare, and GEPASI will be used. |
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Target Audience:
Course Pre-requisites: |
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Detailed Program |
In collaboration with INTERBIO
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Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal Last updated: April 10th 2012 |