SMLMC15 Structural Modelling for Large Macromolecular ComplexesDownloadable poster in PDF |
IMPORTANT DATES for this Course
Candidates with adequate profile will be accepted in the next 72 hours after the application until we reach 20 participants. |
Instructors: |
Joanna Kasprzak started her scientific career in 2006. She obtained Master degree in bioinformatics analysis of enzymes responsible
for RNA modifications. She specialised in protein structure prediction and phylogenetic analysis. In 2013 she got her PhD at the
Adam Mickiewicz University in Poznań, Poland under a supervision of Prof. Janusz M. Bujnicki. Her thesis focused mainly on development of a
software tool for modelling of large macromolecular complexes, PyRy3D, and applying it to prediction of structure
for a complex involved in DNA rapair pathways. The program has been rewarded by Killer Application Award Committee during ISMB/ECCB conference in Vienna
in 2011 and has already gained the trust of the first group of users.
In 2013 she has been hired in International Institute of Molecular and Cell Biology in Warsaw as a Postdoc. Presently, her research focuses mainly on the
modelling of large macromolecular complexes, in particular those involved in DNA repair but also RNA polymerases. Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznań |
Mateusz Dobrychłop is a PhD student in Adam Mickiewicz University in Poznań. In 2010, he started developing PyRy3D Chimera Extension -
a plugin that integrates PyRy3D with a popular molecular viewer UCSF Chimera.
His MSc thesis, defended in 2014, focused on the modelling of highly disordered SF3b complex engaged in splicing, using the PyRy3D suite. |
OverviewWe will present a range of techniques to generate, analyse, and optimise models of proteins, RNA, and their complexes. We will talk about new approaches to structure determination of macromolecules and macromolecular complexes. During the practical sessions participants will learn how to use methods for modelling protein and RNA 3D structures such as Modeller and ModeRNA. Also we will focus on methods dedicated to protein-RNA complexes modelling, e.g. by combining data from low-resolution density maps, SAXS and biochemistry. In particular, we will present how to use PyRy3D, a computational tool to build models of macromolecular complexes based on data from various sources.Participants will be able to bring-in specific biological questions and/or their on data to work with during the course. Target AudienceThe course has been designed for molecular and structural biologists, bioinformaticians and biotechnologists and other scientists interested in modelling of biological complexes. The content is suitable for researchers, both at the graduate and post-graduate levels.Minimal levels of computer usage skills are required. We anticipate the participants to have a wide diversity of interests in biological complexes and their structures. It is likely that they may also aim at getting involved in generating structural models for complexes of interest, but that does not have to be the case for all the participants: they may, for example, just want to explore publicly available data. Course Pre-requisitesGraduate level knowledge in Life Sciences, interest in structural biology. |
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Detailed Program |
Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal Last updated: Mar 15th 2015 |