Automatic Annotation and Data Mining

   Deadline for applications: Feb 14th 2011
   Notification of acceptance dates:
        EARLY: Feb 4th 2011
        NORMAL: Feb 15th 2011
   Course date: Feb 24th - Feb 25th 2011


Stefan Goetz is working as a staff scientist at the Bioinformatics and Genomics Department of the Príncipe Felipe Research Centre (CIPF), Valencia, Spain. After finishing his Computer Science studies in Germany in 2004 he initiated his work in Bioinformatics within the Biomedical Informatics group of the Polytechnic University of Valencia. Here he started to work in the area of Functional Annotation of novel sequences data. Since than he is the major developer within the Blast2GO project. In March 2007 he joined the Bioinformatics Department of the CIPF where he concluded his PhD studies in 2010. During the last years he has been involved in various bioinformatics projects related to the analysis and visualization of genomics data, protein interaction networks, modelling of phenotype information and NGS data processing.

Affiliation Centro de Investigacion Principe Felipe, Valencia, ES

Javier Santoyo-Lopez obtained his PhD in Biological Sciences from the University Autonoma of Madrid (UAM) in 1997. His PhD studies were performed at the Spanish Research Council (CSIC) Centre of Molecular Biology “Severo Ochoa” (Madrid, Spain). After his PhD he moved to Dundee (Scotland, UK) where he obtained his MSc in Bioinformatics at the University of Abertay Dundee. He was a Bioinformatician at the Wellcome Trust Biocentre (Dundee, Scotland, UK), at the Sanger Institute (Hinxton, England, UK), at the Spanish National Cancer Centre - CNIO (Madrid, Spain) and at the Division of Pathway Medicine (Edinburgh, Scotland, UK). Since 2008 he works at the Biomedical Network Research Centre for Rare Diseases (CIBERER) in The Prince Felipe Research Centre – CIPF (Valencia, Spain) where he is involved in the study of genomic variations and regulatory elements that are cause of Rare Diseases. He is also involved in the study of non-coding RNAs, in particular, the study of the RNA interference phenomenon (RNAi).

Affiliation Centro de Investigacion Principe Felipe, Valencia, ES

Course description:

Cost reduction in sequencing technologies is resulting in a growing number of laboratories getting involved in genome sequencing projects where a large amount of sequencing data is generated. After assembly, a large amount of unique sequences are obtained which need to be further characterized with putative functions. Good and sufficient functional annotations are decisive for follow up analyses such as gene expression, strain variations, tissue functional profiling, etc. The course will teach on the principals and practical aspects of automated functional annotation of (novel) sequence data.

Participants will learn how to:
* Create and run standard or costumed pipelines for generating functional labels for sequence data.
* Design annotation strategies and generate different annotation types
* Create a local database installation for annotation speed up
* Evaluate and report the results of the functional annotation pipeline
* Perform data-mining and knowledge discovery using functional annotation and experimental data
* Study similarities and differences between annotation datasets
* Generate and modify knowledge-containing functional annotation graphs

The course will be based on the use of Blast2GO application and will mainly comprise exercises and practical cases. Participants may bring their own data.

Who should attend?> Experimentalists and bioinformaticians working on EST, NextGeneration Sequencing and microarray design projects, specially (but not exclusively) of non-model species. No programming knowledge is required.

NOTE: This course is held immediately after MDA11, a course that we ran many times and trains people in Microarray Data Analysis using one of the most cited software suites for this purpose, that is available for free. You have the choice of applying to AFADM11, MDAGB11,or both; Application forms and Motivation Statements are separate, one for each course, you need to send the CV only once

Course Pre-requisites:

basic knowledge in Molecular Biology and Statistics.

Detailed Program for MDA11
Detailed Program for AFADM11

Instituto Gulbenkian de Ciência,

Apartado 14, 2781-901 Oeiras, Portugal

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Last updated:  Jan 20th 2011